Reaction Details Report a problem with these data
Target
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Ligand
BDBM50402979
Substrate
n/a
Meas. Tech.
ChEMBL_885341 (CHEMBL2215204)
Ki
44840±n/a nM
Citation
 Moorthy, NS; Brás, NF; Ramos, MJ; Fernandes, PA Virtual screening and QSAR study of some pyrrolidine derivatives asa-mannosidase inhibitors for binding feature analysis. Bioorg Med Chem 20:6945-59 (2012) [PubMed]  Article 
Target
Name:
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Synonyms:
MA1B1_HUMAN | MAN1B1
Type:
PROTEIN
Mol. Mass.:
79590.42
Organism:
Homo sapiens (Human)
Description:
ChEMBL_885341
Residue:
699
Sequence:
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENYDNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA
  
Inhibitor
Name:
BDBM50402979
Synonyms:
CHEMBL2207395
Type:
Small organic molecule
Emp. Form.:
C15H23N3O3
Mol. Mass.:
293.3614
SMILES:
CC(=O)N(CNC[C@H]1NC[C@H](O)[C@@H]1O)Cc1ccccc1 |r|
Structure:
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