Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50040243
Substrate
n/a
Meas. Tech.
ChEMBL_58226 (CHEMBL669953)
Ki
30±n/a nM
Citation
 Liégeois, JF; Rogister, FA; Bruhwyler, J; Damas, J; Nguyen, TP; Inarejos, MO; Chleide, EM; Mercier, MG; Delarge, JE Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study. J Med Chem 37:519-25 (1994) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50040243
Synonyms:
8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine(isoclothiapine) | 8-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine | 8-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine | CHEMBL67284
Type:
Small organic molecule
Emp. Form.:
C18H18ClN3S
Mol. Mass.:
343.874
SMILES:
CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Sc2ccccc12 |t:8|
Structure:
Search PDB for entries with ligand similarity: