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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50408106
Substrate
n/a
Meas. Tech.
ChEMBL_66276 (CHEMBL857528)
Ki
14000±n/a nM
Citation
 Dragovich, PS; Barker, JE; French, J; Imbacuan, M; Kalish, VJ; Kissinger, CR; Knighton, DR; Lewis, CT; Moomaw, EW; Parge, HE; Pelletier, LA; Prins, TJ; Showalter, RE; Tatlock, JH; Tucker, KD; Villafranca, JE Structure-based design of novel, urea-containing FKBP12 inhibitors. J Med Chem 39:1872-84 (1996) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50408106
Synonyms:
CHEMBL56927
Type:
Small organic molecule
Emp. Form.:
C23H26N2O3
Mol. Mass.:
378.4641
SMILES:
O=C(OCc1ccccc1)[C@@H]1CCC[C@H]2CCN(Cc3ccccc3)C(=O)N12
Structure:
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