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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50408110
Substrate
n/a
Meas. Tech.
ChEMBL_66276 (CHEMBL857528)
Ki
220±n/a nM
Citation
 Dragovich, PS; Barker, JE; French, J; Imbacuan, M; Kalish, VJ; Kissinger, CR; Knighton, DR; Lewis, CT; Moomaw, EW; Parge, HE; Pelletier, LA; Prins, TJ; Showalter, RE; Tatlock, JH; Tucker, KD; Villafranca, JE Structure-based design of novel, urea-containing FKBP12 inhibitors. J Med Chem 39:1872-84 (1996) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50408110
Synonyms:
CHEMBL293284
Type:
Small organic molecule
Emp. Form.:
C25H32N2O4
Mol. Mass.:
424.5326
SMILES:
CC(C)(C)CNC(=O)N1CCCC[C@H]1C(=O)OCc1cccc(Oc2ccccc2)c1
Structure:
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