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Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50123565
Substrate
n/a
Meas. Tech.
ChEMBL_215891 (CHEMBL820823)
IC50
42.5±n/a nM
Citation
 Ryckebusch, A; Deprez-Poulain, R; Maes, L; Debreu-Fontaine, MA; Mouray, E; Grellier, P; Sergheraert, C Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives. J Med Chem 46:542-57 (2003) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50123565
Synonyms:
(7-Chloro-quinolin-4-yl)-[3-(4-{3-[(quinolin-4-ylmethyl)-amino]-propyl}-piperazin-1-yl)-propyl]-amine | CHEMBL152392
Type:
Small organic molecule
Emp. Form.:
C29H35ClN6
Mol. Mass.:
503.081
SMILES:
Clc1ccc2c(NCCCN3CCN(CCCNCc4ccnc5ccccc45)CC3)ccnc2c1
Structure:
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