Reaction Details
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Calcium-activated potassium channel subunit alpha-1
Ligand
BDBM50412334
Substrate
n/a
Meas. Tech.
ChEMBL_510400 (CHEMBL1000350)
IC50
15848.93±n/a nM
Citation
Calderone, V; Spogli, R; Martelli, A; Manfroni, G; Testai, L; Sabatini, S; Tabarrini, O; Cecchetti, V Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers. J Med Chem 51:5085-92 (2008) [PubMed] Article More Info.:
Target
Name:
Calcium-activated potassium channel subunit alpha-1
Synonyms:
KCMA1_RAT | Kcnma | Kcnma1
Type:
PROTEIN
Mol. Mass.:
134382.76
Organism:
Rattus norvegicus
Description:
ChEMBL_510400
Residue:
1209
Sequence:
MANGGGGGGGGSSGSSGGGGGGGGGETALRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEVVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDVTDPKRIKKCGCRRLEDEQPPTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQKKEMVYR
Inhibitor
Name:
BDBM50412334
Synonyms:
CHEMBL525555
Type:
Small organic molecule
Emp. Form.:
C15H12BrNO2S
Mol. Mass.:
350.23
SMILES:
COc1ccc(Br)cc1C1Sc2ccccc2NC1=O
Structure:
