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Target
D(3) dopamine receptor
Ligand
BDBM50414404
Substrate
n/a
Meas. Tech.
ChEMBL_577522 (CHEMBL1057874)
Ki
2.51±n/a nM
Citation
 Micheli, F; Holmes, I; Arista, L; Bonanomi, G; Braggio, S; Cardullo, F; Di Fabio, R; Donati, D; Gentile, G; Hamprecht, D; Terreni, S; Heidbreder, C; Savoia, C; Griffante, C; Worby, A Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization. Bioorg Med Chem Lett 19:4011-3 (2009) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50414404
Synonyms:
CHEMBL559029
Type:
Small organic molecule
Emp. Form.:
C20H20F3N3O
Mol. Mass.:
375.3875
SMILES:
FC(F)(F)c1cccc(c1)N1CCN(CCN2Cc3ccccc3C2)C1=O
Structure:
Search PDB for entries with ligand similarity: