Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50415290
Substrate
n/a
Meas. Tech.
ChEMBL_605064 (CHEMBL1071926)
Ki
630.96±n/a nM
Citation
 D'Alessandro, PL; Corti, C; Roth, A; Ugolini, A; Sava, A; Montanari, D; Bianchi, F; Garland, SL; Powney, B; Koppe, EL; Rocheville, M; Osborne, G; Perez, P; de la Fuente, J; De Los Frailes, M; Smith, PW; Branch, C; Nash, D; Watson, SP The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2. Bioorg Med Chem Lett 20:759-62 (2010) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50415290
Synonyms:
CHEMBL603443
Type:
Small organic molecule
Emp. Form.:
C20H21F3N4
Mol. Mass.:
374.4027
SMILES:
Cn1c(CN2CCN(CC2)c2ccccc2C(F)(F)F)nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: