Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50417398
Substrate
n/a
Meas. Tech.
ChEMBL_686319 (CHEMBL1293075)
Ki
5.01±n/a nM
Citation
 Pizzi, DA; Leslie, CP; Mazzali, A; Seri, C; Biagetti, M; Bentley, J; Genski, T; Di Fabio, R; Contini, S; Sabbatini, FM; Zonzini, L; Caberlotto, L Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists. Bioorg Med Chem Lett 20:7120-3 (2010) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50417398
Synonyms:
CHEMBL1289387
Type:
Small organic molecule
Emp. Form.:
C23H22F3N3O3
Mol. Mass.:
445.4343
SMILES:
Cc1ccccc1N1C[C@@]2(CC[C@@H](CC2)c2nc3ccc(OC(F)(F)F)cc3[nH]2)OC1=O |r,wU:9.32,wD:12.16,(1.99,-19.59,;3.32,-20.37,;4.65,-19.62,;5.99,-20.4,;5.97,-21.94,;4.63,-22.69,;3.3,-21.91,;1.97,-22.66,;.57,-22.02,;-.47,-23.15,;-1.22,-24.5,;-2.75,-24.53,;-3.55,-23.22,;-2.82,-21.87,;-1.27,-21.84,;-5.08,-23.25,;-5.96,-24.52,;-7.45,-24.08,;-8.76,-24.88,;-10.11,-24.14,;-10.15,-22.6,;-11.51,-21.86,;-11.54,-20.32,;-12.89,-19.58,;-10.22,-19.52,;-11.5,-18.78,;-8.84,-21.8,;-7.49,-22.53,;-6.02,-22.02,;.29,-24.49,;1.79,-24.19,;2.93,-25.23,)|
Structure:
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