Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50417401
Substrate
n/a
Meas. Tech.
ChEMBL_686319 (CHEMBL1293075)
Ki
2.51±n/a nM
Citation
 Pizzi, DA; Leslie, CP; Mazzali, A; Seri, C; Biagetti, M; Bentley, J; Genski, T; Di Fabio, R; Contini, S; Sabbatini, FM; Zonzini, L; Caberlotto, L Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists. Bioorg Med Chem Lett 20:7120-3 (2010) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50417401
Synonyms:
CHEMBL1289502
Type:
Small organic molecule
Emp. Form.:
C22H19ClF3N3O3
Mol. Mass.:
465.853
SMILES:
FC(F)(F)Oc1ccc2nc([nH]c2c1)[C@H]1CC[C@@]2(CN(C(=O)O2)c2ccccc2Cl)CC1 |r,wU:17.24,wD:14.15,(7.52,-20.4,;8.87,-21.14,;10.19,-20.34,;8.91,-19.6,;8.91,-22.68,;10.26,-23.42,;10.29,-24.96,;11.65,-25.7,;12.96,-24.9,;14.44,-25.34,;15.32,-24.07,;14.38,-22.84,;12.92,-23.35,;11.57,-22.62,;16.86,-24.04,;17.66,-25.35,;19.19,-25.32,;19.94,-23.97,;20.98,-22.84,;22.38,-23.48,;22.2,-25.01,;23.34,-26.05,;20.7,-25.31,;23.71,-22.73,;25.04,-23.52,;26.38,-22.76,;26.4,-21.22,;25.06,-20.44,;23.73,-21.19,;22.4,-20.41,;19.14,-22.66,;17.59,-22.69,)|
Structure:
Search PDB for entries with ligand similarity: