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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50419490
Substrate
n/a
Meas. Tech.
ChEMBL_789189 (CHEMBL1924273)
IC50
0.631±n/a nM
Citation
 Mete, A; Bowers, K; Chevalier, E; Donald, DK; Edwards, H; Escott, KJ; Ford, R; Grime, K; Millichip, I; Teobald, B; Russell, V The discovery of AZD9164, a novel muscarinic M3 antagonist. Bioorg Med Chem Lett 21:7440-6 (2011) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50419490
Synonyms:
CHEMBL1921929
Type:
Small organic molecule
Emp. Form.:
C29H39N2O3
Mol. Mass.:
463.631
SMILES:
C[C@@](N1CCCCC1)(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1 |r,wU:1.0,wD:1.8,11.11,(9.51,2.28,;9.52,3.82,;9.52,5.36,;10.86,6.13,;10.86,7.68,;9.52,8.46,;8.18,7.68,;8.18,6.12,;10.87,3.04,;10.87,1.5,;12.2,3.83,;13.55,3.05,;13.55,1.51,;14.88,.75,;14.87,-.79,;16.19,-1.57,;17.53,-.81,;18.86,-1.59,;18.85,-3.12,;20.17,-3.89,;21.5,-3.13,;21.5,-1.59,;20.18,-.82,;16.22,1.51,;16.22,3.05,;14.88,3.84,;14.1,2.51,;15.58,2.11,;8.19,3.06,;6.86,3.85,;5.52,3.09,;5.51,1.55,;6.84,.77,;8.18,1.53,)|
Structure:
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