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Target
Neutrophil collagenase
Ligand
BDBM50081852
Substrate
n/a
Meas. Tech.
ChEMBL_458937 (CHEMBL924956)
IC50
4.0±n/a nM
Citation
 Verma, RP; Hansch, C Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. Bioorg Med Chem 15:2223-68 (2007) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50081852
Synonyms:
(2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-methylnaphthalene-1-sulfonamido)methyl)-4-oxo-4-(piperidin-1-yl)butanamide | (2R,3R)-3-Cyclopentylmethyl-N-hydroxy-2-{[methyl-(naphthalene-1-sulfonyl)-amino]-methyl}-4-oxo-4-piperidin-1-yl-butyramide | CHEMBL97936
Type:
Small organic molecule
Emp. Form.:
C27H37N3O5S
Mol. Mass.:
515.665
SMILES:
CN(C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO)S(=O)(=O)c1cccc2ccccc12
Structure:
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