Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50423558
Substrate
n/a
Meas. Tech.
ChEMBL_468124 (CHEMBL934144)
IC50
7.9±n/a nM
Citation
 Hall, A; Bit, RA; Brown, SH; Chowdhury, A; Giblin, GM; Hurst, DN; Kilford, IR; Lewell, X; Naylor, A; Scoccitti, T Novel methylene-linked heterocyclic EP1 receptor antagonists. Bioorg Med Chem Lett 18:1592-7 (2008) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50423558
Synonyms:
CHEMBL255009
Type:
Small organic molecule
Emp. Form.:
C15H15ClNO3S
Mol. Mass.:
324.803
SMILES:
CC(C)COc1ccc(Cl)cc1Cc1nc(cs1)C([O-])=O
Structure:
Search PDB for entries with ligand similarity: