Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50423981
Substrate
n/a
Meas. Tech.
ChEMBL_935597 (CHEMBL2320379)
IC50
24500±n/a nM
Citation
 Zhang, XS; Bi, XL; Wan-Xiao, na; Cao, JQ; Xia, XC; Diao, YP; Zhao, YQ Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins. Bioorg Med Chem Lett 23:297-300 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50423981
Synonyms:
GYPENSAPOGENIN B
Type:
Small organic molecule
Emp. Form.:
C30H42O2
Mol. Mass.:
434.6533
SMILES:
[#6]\[#6](-[#6])=[#6]-1\[#6]-[#6](=[#6]-[#6]-1=O)-[#6@H]-1-[#6]-[#6][C@]2([#6])[#6@@H]-1-[#6]-[#6]-[#6@@H]1-[#6]-3=[#6](-[#6]-[#6][C@@]21[#6])C([#6])([#6])[#6@@H]-1-[#6]-[#6]-[#6@H]-3-[#8]-1 |r,c:5,20|
Structure:
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