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Target
Cathepsin B
Ligand
BDBM64987
Substrate
n/a
Meas. Tech.
ChEMBL_936328 (CHEMBL2321260)
Ki
154400±n/a nM
Citation
 Sosic, I; Mirkovic, B; Arenz, K; Stefane, B; Kos, J; Gobec, S Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives. J Med Chem 56:521-33 (2013) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM64987
Synonyms:
5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HYDROXY-5-NITROQUINOLINE | MLS000069750 | SMR000059036 | cid_19910 | nitroxoline
Type:
Small organic molecule
Emp. Form.:
C9H6N2O3
Mol. Mass.:
190.1555
SMILES:
Oc1ccc([N+]([O-])=O)c2cccnc12
Structure:
Search PDB for entries with ligand similarity: