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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50426383
Substrate
n/a
Meas. Tech.
ChEMBL_939959 (CHEMBL2327511)
IC50
>50000±n/a nM
Citation
 Huh, JR; Englund, EE; Wang, H; Huang, R; Huang, P; Rastinejad, F; Inglese, J; Austin, CP; Johnson, RL; Huang, W; Littman, DR Identification of Potent and Selective Diphenylpropanamide ROR? Inhibitors. ACS Med Chem Lett 4:79-84 (2013) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50426383
Synonyms:
CHEMBL1445011
Type:
Small organic molecule
Emp. Form.:
C22H27NO6
Mol. Mass.:
401.4529
SMILES:
CCN(CC)C(=O)CC(c1ccc2OCOc2c1)c1c(O)cc(OC)cc1OC
Structure:
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