Reaction Details Report a problem with these data
Target
Farnesyl diphosphate synthase
Ligand
BDBM50426978
Substrate
n/a
Meas. Tech.
ChEMBL_939177 (CHEMBL2329369)
IC50
>10000±n/a nM
Citation
 Recher, M; Barboza, AP; Li, ZH; Galizzi, M; Ferrer-Casal, M; Szajnman, SH; Docampo, R; Moreno, SN; Rodriguez, JB Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents. Eur J Med Chem 60:431-40 (2013) [PubMed]  Article 
Target
Name:
Farnesyl diphosphate synthase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
48827.21
Organism:
Trypanosoma cruzi
Description:
ChEMBL_939177
Residue:
425
Sequence:
MTAFACFPHSLFYSTRLPFFFFFFCVCVHCCLRYLCLLKCAYCCSDKNYFRPLNYFFYCLYLAMASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLLVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGEKDPAKVAVVKRLYSKANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRKK
  
Inhibitor
Name:
BDBM50426978
Synonyms:
CHEMBL2326233
Type:
Small organic molecule
Emp. Form.:
C6H16O7P2S
Mol. Mass.:
294.2
SMILES:
CCCCS(=O)CC(P(O)(O)=O)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: