Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM50146456
Substrate
n/a
Meas. Tech.
ChEMBL_938788 (CHEMBL2327932)
IC50
6269000±n/a nM
Citation
 Katane, M; Osaka, N; Matsuda, S; Maeda, K; Kawata, T; Saitoh, Y; Sekine, M; Furuchi, T; Doi, I; Hirono, S; Homma, H Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. J Med Chem 56:1894-907 (2013) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM50146456
Synonyms:
(2E)-3-(3-hydroxyphenyl)-2-propenoic acid | (2E)-3-(3-hydroxyphenyl)acrylic acid | (2E)-3-(3-hydroxyphenyl)prop-2-enoic acid | (E)-3-(3-hydroxyphenyl)-2-propenoic acid | 3-Coumaric acid | CHEMBL98521 | trans-3-Hydroxycinnamate | trans-3-coumaric acid
Type:
Small organic molecule
Emp. Form.:
C9H8O3
Mol. Mass.:
164.158
SMILES:
OC(=O)\C=C\c1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity: