Reaction Details Report a problem with these data
Target
Gastricsin
Ligand
BDBM50427564
Substrate
n/a
Meas. Tech.
ChEMBL_941699 (CHEMBL2330922)
IC50
>30000±n/a nM
Citation
Lorthiois, E; Breitenstein, W; Cumin, F; Ehrhardt, C; Francotte, E; Jacoby, E; Ostermann, N; Sellner, H; Kosaka, T; Webb, RL; Rigel, DF; Hassiepen, U; Richert, P; Wagner, T; Maibaum, J The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches. J Med Chem 56:2207-17 (2013) [PubMed] Article
More Info.:
Target
Name:
Gastricsin
Synonyms:
Gastricsin | PEPC_HUMAN | PGC | Pepsinogen C
Type:
PROTEIN
Mol. Mass.:
42409.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1452207
Residue:
388
Sequence:
MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA