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Target
Transmembrane protease serine 4
Ligand
BDBM50430180
Substrate
n/a
Meas. Tech.
ChEMBL_942945 (CHEMBL2343323)
IC50
30000±n/a nM
Citation
 Kang, S; Min, HJ; Kang, MS; Jung, MG; Kim, S Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors. Bioorg Med Chem Lett 23:1748-51 (2013) [PubMed]  Article 
Target
Name:
Transmembrane protease serine 4
Synonyms:
CAPH2 | Channel-activating protease 2 | MT-SP2 | Membrane-type serine protease 2 | TMPRSS3 | TMPRSS4 | TMPS4_HUMAN
Type:
PROTEIN
Mol. Mass.:
48237.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942945
Residue:
437
Sequence:
MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL
  
Inhibitor
Name:
BDBM50430180
Synonyms:
CHEMBL2313089
Type:
Small organic molecule
Emp. Form.:
C14H8BrClF3NO2
Mol. Mass.:
394.571
SMILES:
Oc1ccc(Cl)cc1C(=O)Nc1ccc(Br)c(c1)C(F)(F)F
Structure:
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