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Target
Translocator protein
Ligand
BDBM50430880
Substrate
n/a
Meas. Tech.
ChEMBL_945907 (CHEMBL2340521)
Ki
>500±n/a nM
Citation
 Tang, D; McKinley, ET; Hight, MR; Uddin, MI; Harp, JM; Fu, A; Nickels, ML; Buck, JR; Manning, HC Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. J Med Chem 56:3429-33 (2013) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50430880
Synonyms:
CHEMBL2336481
Type:
Small organic molecule
Emp. Form.:
C25H34N4O2
Mol. Mass.:
422.5631
SMILES:
CCN(CC)C(=O)Cc1c(nn2c(cc(nc12)C(C)C)C(C)C)-c1ccc(OC)cc1
Structure:
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