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Target
Streptokinase
Ligand
BDBM50431672
Substrate
n/a
Meas. Tech.
ChEMBL_951237 (CHEMBL2353238)
IC50
3200±n/a nM
Citation
 Yestrepsky, BD; Xu, Y; Breen, ME; Li, X; Rajeswaran, WG; Ryu, JG; Sorenson, RJ; Tsume, Y; Wilson, MW; Zhang, W; Sun, D; Sun, H; Larsen, SD Novel inhibitors of bacterial virulence: development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression. Bioorg Med Chem 21:1880-97 (2013) [PubMed]  Article 
Target
Name:
Streptokinase
Synonyms:
STRQ_STRPY | ska
Type:
PROTEIN
Mol. Mass.:
49905.98
Organism:
Streptococcus pyogenes
Description:
ChEMBL_1295409
Residue:
440
Sequence:
MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLGRPSVNNSQLVVSVAGTVEGTNQEISLKFFEIDLTSRPAQGGKTEQGLRPKSKPLATDKGAMSHKLEKADLLKAIQEQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQEFLLSGHVRVRPYRPKAVHNSAERVNVNYEVSFVSETGNLDFTPSLKEQYHLTTLAVGDSLSSQELAAIAQFILSKKHPDYIITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIEEKTNNTDLISEKYYILKKGEKPYDPFDRSHLKLFTIKYVDVDTKALLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMGYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEEREVYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM50431672
Synonyms:
CHEMBL2349411
Type:
Small organic molecule
Emp. Form.:
C20H24N2O2S
Mol. Mass.:
356.482
SMILES:
COCCSc1nc2-c3ccccc3CC(C)(C)c2c(=O)n1CC=C
Structure:
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