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Target
Histamine H3 receptor
Ligand
BDBM50433194
Substrate
n/a
Meas. Tech.
ChEMBL_957095 (CHEMBL2378560)
Ki
6.9±n/a nM
Citation
 Labeeuw, O; Levoin, N; Poupardin-Olivier, O; Calmels, T; Ligneau, X; Berrebi-Bertrand, I; Robert, P; Lecomte, JM; Schwartz, JC; Capet, M Novel and highly potent histamine H3 receptor ligands. Part 3: an alcohol function to improve the pharmacokinetic profile. Bioorg Med Chem Lett 23:2548-54 (2013) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_MOUSE | Hrh3
Type:
PROTEIN
Mol. Mass.:
48560.37
Organism:
Mus musculus
Description:
ChEMBL_988451
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50433194
Synonyms:
CHEMBL2375587
Type:
Small organic molecule
Emp. Form.:
C20H31NO2
Mol. Mass.:
317.4656
SMILES:
O[C@H]1CC[C@@H](CC1)c1ccc(OCCCN2CCCCC2)cc1 |r,wU:1.0,wD:4.7,(47.57,-42.13,;46.23,-42.89,;46.22,-44.43,;44.89,-45.19,;43.57,-44.41,;43.56,-42.88,;44.9,-42.11,;42.23,-45.18,;42.22,-46.72,;40.89,-47.49,;39.56,-46.71,;38.23,-47.47,;36.9,-46.7,;35.56,-47.46,;34.23,-46.69,;32.89,-47.46,;31.56,-46.68,;30.23,-47.46,;30.23,-49,;31.56,-49.76,;32.89,-49,;39.56,-45.17,;40.89,-44.41,)|
Structure:
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