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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50435355
Substrate
n/a
Meas. Tech.
ChEMBL_965509 (CHEMBL2395457)
IC50
>10000±n/a nM
Citation
 Zheng, X; Bauer, P; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Han, B; Ho, YC; Kley, N; Lin, J; Reynolds, DJ; Sharma, G; Smith, CC; Wang, Z; Dragovich, PS; Oh, A; Wang, W; Zak, M; Gunzner-Toste, J; Zhao, G; Yuen, PW; Bair, KW Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. J Med Chem 56:4921-37 (2013) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50435355
Synonyms:
CHEMBL2391569
Type:
Small organic molecule
Emp. Form.:
C13H13N3S
Mol. Mass.:
243.327
SMILES:
S=C(NCc1cccnc1)Nc1ccccc1
Structure:
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