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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50437463
Substrate
n/a
Meas. Tech.
ChEMBL_974577 (CHEMBL2410165)
IC50
491±n/a nM
Citation
 Wang, QQ; Cheng, N; Zheng, XW; Peng, SM; Zou, XQ Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors. Bioorg Med Chem 21:4301-10 (2013) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50437463
Synonyms:
CHEMBL2409469
Type:
Small organic molecule
Emp. Form.:
C21H21NO9
Mol. Mass.:
431.3927
SMILES:
Oc1ccc(cc1O)-c1cc([O-])c2c(cc(OCCCCCCO[N+]([O-])=O)cc2=[OH+])o1
Structure:
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