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Target
Hexokinase-4
Ligand
BDBM50437905
Substrate
n/a
Meas. Tech.
ChEMBL_974049 (CHEMBL2410527)
EC50
9200±n/a nM
Citation
 Filipski, KJ; Guzman-Perez, A; Bian, J; Perreault, C; Aspnes, GE; Didiuk, MT; Dow, RL; Hank, RF; Jones, CS; Maguire, RJ; Tu, M; Zeng, D; Liu, S; Knafels, JD; Litchfield, J; Atkinson, K; Derksen, DR; Bourbonais, F; Gajiwala, KS; Hickey, M; Johnson, TO; Humphries, PS; Pfefferkorn, JA Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif. Bioorg Med Chem Lett 23:4571-8 (2013) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50437905
Synonyms:
CHEMBL2408116
Type:
Small organic molecule
Emp. Form.:
C21H19N3O5S
Mol. Mass.:
425.458
SMILES:
CC(C)Oc1cc(Oc2ccc(cc2)S(C)(=O)=O)cc(c1)-c1ncc(C#N)c(=O)[nH]1
Structure:
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