Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50437991
Substrate
n/a
Meas. Tech.
ChEMBL_972954 (CHEMBL2412035)
IC50
7.0±n/a nM
Citation
 Crocetti, L; Schepetkin, IA; Cilibrizzi, A; Graziano, A; Vergelli, C; Giomi, D; Khlebnikov, AI; Quinn, MT; Giovannoni, MP Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. J Med Chem 56:6259-72 (2013) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50437991
Synonyms:
CHEMBL2409450
Type:
Small organic molecule
Emp. Form.:
C16H11N3O
Mol. Mass.:
261.278
SMILES:
Cc1cccc(c1)C(=O)n1nc(C#N)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: