Reaction Details Report a problem with these data
Target
Acetylcholinesterase
Ligand
BDBM26664
Substrate
n/a
Meas. Tech.
ChEMBL_986889 (CHEMBL2438753)
IC50
85000±n/a nM
Citation
 Li, SY; Wang, XB; Xie, SS; Jiang, N; Wang, KD; Yao, HQ; Sun, HB; Kong, LY Multifunctional tacrine-flavonoid hybrids with cholinergic,ß-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease. Eur J Med Chem 69:632-46 (2013) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache
Type:
Enzyme
Mol. Mass.:
71812.79
Organism:
Electrophorus electricus (Electric eel)
Description:
n/a
Residue:
633
Sequence:
MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFAEPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLYLNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGFLALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDSRPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLIDQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYGAPGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIVGDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHRASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINVDGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAERQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
  
Inhibitor
Name:
BDBM26664
Synonyms:
7-Hydroxy-flavone, 5a | 7-Hydroxyflavone, 11 | 7-hydroxy-2-phenyl-4H-chromen-4-one | 7-hydroxyflavone | CHEMBL276915
Type:
Flavonoid
Emp. Form.:
C15H10O3
Mol. Mass.:
238.2381
SMILES:
Oc1ccc2c(c1)oc(cc2=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: