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Target
Acyl-CoA desaturase 1
Ligand
BDBM50443713
Substrate
n/a
Meas. Tech.
ChEMBL_1279690 (CHEMBL3094880)
IC50
29±n/a nM
Citation
 Yang, SM; Tang, Y; Zhang, R; Lu, H; Kuo, GH; Gaul, MD; Li, Y; Ho, G; Conway, JG; Liang, Y; Lenhard, JM; Demarest, KT; Murray, WV 4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs. Bioorg Med Chem Lett 23:6773-6 (2013) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50443713
Synonyms:
CHEMBL3093860 | US9238658, 36
Type:
Small organic molecule
Emp. Form.:
C20H24FN5OS
Mol. Mass.:
401.501
SMILES:
Fc1ccc2CCN(C3CCN(CC3)C(=O)Nc3nc4CCNCc4s3)c2c1
Structure:
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