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Target
Coagulation factor X
Ligand
BDBM50444529
Substrate
n/a
Meas. Tech.
ChEMBL_1281384 (CHEMBL3101479)
Ki
1200±n/a nM
Citation
 Goswami, R; Mukherjee, S; Wohlfahrt, G; Ghadiyaram, C; Nagaraj, J; Chandra, BR; Sistla, RK; Satyam, LK; Samiulla, DS; Moilanen, A; Subramanya, HS; Ramachandra, M Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors. ACS Med Chem Lett 4:1152-7 (2013) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50444529
Synonyms:
CHEMBL3099588
Type:
Small organic molecule
Emp. Form.:
C19H18N6O2
Mol. Mass.:
362.3852
SMILES:
NC(=N)c1ccc(Oc2ccc(N)c(Oc3ccc(cc3)C(N)=N)n2)cc1
Structure:
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