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Target
Kallikrein-5 [D153N]
Ligand
BDBM50444602
Substrate
n/a
Meas. Tech.
ChEMBL_1282444 (CHEMBL3100871)
Ki
100000±n/a nM
Citation
 Tan, X; Bertonati, C; Qin, L; Furio, L; El Amri, C; Hovnanian, A; Reboud-Ravaux, M; Villoutreix, BO Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins. Eur J Med Chem 70:661-8 (2013) [PubMed]  Article 
Target
Name:
Kallikrein-5 [D153N]
Synonyms:
KLK-L2 | KLK5 | KLK5_HUMAN | Kallikrein 5 | Kallikrein-5 | Kallikrein-like protein 2 | SCTE | Stratum corneum tryptic enzyme
Type:
PROTEIN
Mol. Mass.:
32031.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1282456
Residue:
293
Sequence:
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNNLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS
  
Inhibitor
Name:
BDBM50444602
Synonyms:
CHEMBL3099874
Type:
Small organic molecule
Emp. Form.:
C18H16N2O4
Mol. Mass.:
324.3306
SMILES:
COc1ccc(NC(=O)C(=C/c2ccc(O)c(OC)c2)\C#N)cc1
Structure:
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