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Target
Glutathione reductase, mitochondrial
Ligand
BDBM50264834
Substrate
n/a
Meas. Tech.
ChEMBL_1284129 (CHEMBL3107513)
IC50
>100000±n/a nM
Citation
 Braga, SF; Alves, ÉV; Ferreira, RS; Fradico, JR; Lage, PS; Duarte, MC; Ribeiro, TG; Júnior, PA; Romanha, AJ; Tonini, ML; Steindel, M; Coelho, EF; de Oliveira, RB Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones. Eur J Med Chem 71:282-9 (2014) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50264834
Synonyms:
2,6-bis(4-methylbenzylidene)cyclohexanone | CHEMBL502160
Type:
Small organic molecule
Emp. Form.:
C22H22O
Mol. Mass.:
302.4095
SMILES:
Cc1ccc(\C=C2/CCC\C(=C/c3ccc(C)cc3)C2=O)cc1
Structure:
Search PDB for entries with ligand similarity: