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Target
Ezrin
Ligand
BDBM50445470
Substrate
n/a
Meas. Tech.
ChEMBL_1284145 (CHEMBL3107613)
Kd
40100±n/a nM
Citation
 Paige, M; Kosturko, G; Bulut, G; Miessau, M; Rahim, S; Toretsky, JA; Brown, ML; Üren, A Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma. Bioorg Med Chem 22:478-87 (2013) [PubMed]  Article 
Target
Name:
Ezrin
Synonyms:
Cytovillin | EZR | EZRI_HUMAN | VIL2 | Villin-2 | p81
Type:
Protein
Mol. Mass.:
69408.95
Organism:
Homo sapiens (Human)
Description:
P15311
Residue:
586
Sequence:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
  
Inhibitor
Name:
BDBM50445470
Synonyms:
CHEMBL3104716
Type:
Small organic molecule
Emp. Form.:
C17H12Br2N2O3
Mol. Mass.:
452.097
SMILES:
Oc1cc(N=CCc2cc(Br)c(O)c(Br)c2)c(O)c2cnccc12 |w:4.3|
Structure:
Search PDB for entries with ligand similarity: