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Target
Protein-arginine deiminase type-3
Ligand
BDBM50447760
Substrate
n/a
Meas. Tech.
ChEMBL_1290378 (CHEMBL3119093)
IC50
710±n/a nM
Citation
 Dreyton, CJ; Anderson, ED; Subramanian, V; Boger, DL; Thompson, PR Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem 22:1362-9 (2014) [PubMed]  Article 
Target
Name:
Protein-arginine deiminase type-3
Synonyms:
PAD3 | PADI3 | PADI3_HUMAN | PDI3 | Peptidylarginine deiminase III | Protein-arginine deiminase type III
Type:
PROTEIN
Mol. Mass.:
74727.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1290378
Residue:
664
Sequence:
MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEVYGTPGVDIYISPNMERGRERADTRRWRFDATLEIIVVMNSPSNDLNDSHVQISYHSSHEPLPLAYAVLYLTCVDISLDCDLNCEGRQDRNFVDKRQWVWGPSGYGGILLVNCDRDDPSCDVQDNCDQHVHCLQDLEDMSVMVLRTQGPAALFDDHKLVLHTSSYDAKRAQVFHICGPEDVCEAYRHVLGQDKVSYEVPRLHGDEERFFVEGLSFPDAGFTGLISFHVTLLDDSNEDFSASPIFTDTVVFRVAPWIMTPSTLPPLEVYVCRVRNNTCFVDAVAELARKAGCKLTICPQAENRNDRWIQDEMELGYVQAPHKTLPVVFDSPRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSSGRRVTQVVRDFLHAQKVQPPVELFVDWLAVGHVDEFLSFVPAPDGKGFRMLLASPGACFKLFQEKQKCGHGRALLFQGVVDDEQVKTISINQVLSNKDLINYNKFVQSCIDWNREVLKRELGLAECDIIDIPQLFKTERKKATAFFPDLVNMLVLGKHLGIPKPFGPIINGCCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVCRKPFSFKWWNMVP
  
Inhibitor
Name:
BDBM50447760
Synonyms:
CHEMBL58150
Type:
Small organic molecule
Emp. Form.:
C15H9N3O4
Mol. Mass.:
295.2497
SMILES:
NC1=CC(=O)c2ccc(nc2C1=O)-c1cccc(n1)C(O)=O |t:1|
Structure:
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