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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50448457
Substrate
n/a
Meas. Tech.
ChEMBL_1297287 (CHEMBL3132073)
IC50
>100000±n/a nM
Citation
 Tanaka, Y; Aikawa, K; Nishida, G; Homma, M; Sogabe, S; Igaki, S; Hayano, Y; Sameshima, T; Miyahisa, I; Kawamoto, T; Tawada, M; Imai, Y; Inazuka, M; Cho, N; Imaeda, Y; Ishikawa, T Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins. J Med Chem 56:9635-45 (2014) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50448457
Synonyms:
CHEMBL3126114
Type:
Small organic molecule
Emp. Form.:
C26H31ClN2O2
Mol. Mass.:
438.99
SMILES:
CC1(C)CCC(=C(CN2CCN(CC2)c2ccc(cc2)C(O)=O)C1)c1ccc(Cl)cc1 |t:5|
Structure:
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