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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50001057
Substrate
n/a
Meas. Tech.
ChEMBL_1337655 (CHEMBL3242843)
IC50
28690±n/a nM
Citation
 Chatzopoulou, M; Patsilinakos, A; Vallianatou, T; Prnova, MS; Zakelj, S; Ragno, R; Stefek, M; Kristl, A; Tsantili-Kakoulidou, A; Demopoulos, VJ Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation. Bioorg Med Chem 22:2194-207 (2014) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50001057
Synonyms:
CHEMBL3236008
Type:
Small organic molecule
Emp. Form.:
C18H14FNO3
Mol. Mass.:
311.3071
SMILES:
COc1cccc(c1)C(=O)c1ccn(c1)-c1ccc(O)c(F)c1
Structure:
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