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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50001058
Substrate
n/a
Meas. Tech.
ChEMBL_1337655 (CHEMBL3242843)
IC50
>100000±n/a nM
Citation
 Chatzopoulou, M; Patsilinakos, A; Vallianatou, T; Prnova, MS; Zakelj, S; Ragno, R; Stefek, M; Kristl, A; Tsantili-Kakoulidou, A; Demopoulos, VJ Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation. Bioorg Med Chem 22:2194-207 (2014) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50001058
Synonyms:
CHEMBL3236009
Type:
Small organic molecule
Emp. Form.:
C18H11F4NO3
Mol. Mass.:
365.2785
SMILES:
Oc1ccc(cc1F)-n1ccc(c1)C(=O)c1ccc(OC(F)(F)F)cc1
Structure:
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