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Target
Caspase-7
Ligand
BDBM50002743
Substrate
n/a
Meas. Tech.
ChEMBL_1339381 (CHEMBL3243715)
IC50
4794±n/a nM
Citation
 Wu, L; Lu, M; Yan, Z; Tang, X; Sun, B; Liu, W; Zhou, H; Yang, C 1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors. Bioorg Med Chem 22:2416-26 (2014) [PubMed]  Article 
Target
Name:
Caspase-7
Synonyms:
Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase
Type:
Enzyme
Mol. Mass.:
34273.91
Organism:
Homo sapiens (Human)
Description:
P55210
Residue:
303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
  
Inhibitor
Name:
BDBM50002743
Synonyms:
CHEMBL3233641
Type:
Small organic molecule
Emp. Form.:
C18H17N3O5S2
Mol. Mass.:
419.475
SMILES:
O=C(Nc1ccc(cc1)S(=O)(=O)N1CCOCC1)n1sc2ccccc2c1=O
Structure:
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