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Target
Casein kinase I isoform delta
Ligand
BDBM50008406
Substrate
n/a
Meas. Tech.
ChEMBL_1334961 (CHEMBL3239314)
IC50
68±n/a nM
Citation
 Salado, IG; Redondo, M; Bello, ML; Perez, C; Liachko, NF; Kraemer, BC; Miguel, L; Lecourtois, M; Gil, C; Martinez, A; Perez, DI Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. J Med Chem 57:2755-72 (2014) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50008406
Synonyms:
CHEMBL3235542
Type:
Small organic molecule
Emp. Form.:
C16H10ClF3N2OS
Mol. Mass.:
370.777
SMILES:
FC(F)(F)c1ccc2nc(NC(=O)Cc3ccccc3Cl)sc2c1
Structure:
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