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Target
Dipeptidyl peptidase 2
Ligand
BDBM50009354
Substrate
n/a
Meas. Tech.
ChEMBL_1335499 (CHEMBL3239284)
IC50
>100000±n/a nM
Citation
 Jansen, K; Heirbaut, L; Verkerk, R; Cheng, JD; Joossens, J; Cos, P; Maes, L; Lambeir, AM; De Meester, I; Augustyns, K; Van der Veken, P Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). J Med Chem 57:3053-74 (2014) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 2
Synonyms:
DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase
Type:
Protein
Mol. Mass.:
54339.29
Organism:
Homo sapiens (Human)
Description:
Q9UHL4
Residue:
492
Sequence:
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
  
Inhibitor
Name:
BDBM50009354
Synonyms:
CHEMBL3233573
Type:
Small organic molecule
Emp. Form.:
C20H17FN6O2
Mol. Mass.:
392.3864
SMILES:
Fc1ccc(cc1)-c1nc2c(ccnc2[nH]1)C(=O)NCC(=O)N1CCC[C@H]1C#N |r|
Structure:
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