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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM50016500
Substrate
n/a
Meas. Tech.
ChEMBL_1347480 (CHEMBL3268272)
IC50
1050±n/a nM
Citation
 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Aromatic diacylhydrazine derivatives as a new class of polo-like kinase 1 (PLK1) inhibitors. Eur J Med Chem 81:420-6 (2014) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM50016500
Synonyms:
CHEMBL3260246
Type:
Small organic molecule
Emp. Form.:
C19H18N2O4
Mol. Mass.:
338.3572
SMILES:
Cc1ccc(\C=C\C(=O)NNC(=O)c2ccc3OCCOc3c2)cc1
Structure:
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