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Target
Neutrophil elastase
Ligand
BDBM50016905
Substrate
n/a
Meas. Tech.
ChEMBL_1357228 (CHEMBL3284360)
Ki
36000±n/a nM
Citation
 Dorn, CP; Zimmerman, M; Yang, SS; Yurewicz, EC; Ashe, BM; Frankshun, R; Jones, H Proteinase inhibitors. I. Inhibitors of elastase. J Med Chem 20:1464-8 (1977) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50016905
Synonyms:
CHEMBL3273010
Type:
Small organic molecule
Emp. Form.:
C19H32N6O7
Mol. Mass.:
456.4934
SMILES:
CNC(=O)[C@H](C)OC(=O)N(C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(C)=O |r|
Structure:
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