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Target
Proteasome subunit beta type-7
Ligand
BDBM50018677
Substrate
n/a
Meas. Tech.
ChEMBL_1362841 (CHEMBL3295791)
IC50
2300±n/a nM
Citation
 Kawamura, S; Unno, Y; Asai, A; Arisawa, M; Shuto, S Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones. Bioorg Med Chem 22:3091-5 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-7
Synonyms:
Macropain chain Z | Multicatalytic endopeptidase complex chain Z | PSB7_HUMAN | PSMB7 | Proteasome subunit Z | Z
Type:
PROTEIN
Mol. Mass.:
29968.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
277
Sequence:
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
  
Inhibitor
Name:
BDBM50018677
Synonyms:
CHEMBL3291290
Type:
Small organic molecule
Emp. Form.:
C34H47N3O7
Mol. Mass.:
609.7529
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)C(=O)[C@@]1(C)CO1 |r|
Structure:
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