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Target
Prostaglandin D2 receptor
Ligand
BDBM50018898
Substrate
n/a
Meas. Tech.
ChEMBL_1364479 (CHEMBL3295027)
IC50
350±n/a nM
Citation
 Johnson, MG; Liu, JJ; Li, AR; van Lengerich, B; Wang, S; Medina, JC; Collins, TL; Danao, J; Seitz, L; Willee, A; D'Souza, W; Budelsky, AL; Fan, PW; Wong, SG Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP. Bioorg Med Chem Lett 24:2877-80 (2014) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor
Synonyms:
PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor
Type:
Enzyme
Mol. Mass.:
40288.87
Organism:
Homo sapiens (Human)
Description:
Q13258
Residue:
359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
  
Inhibitor
Name:
BDBM50018898
Synonyms:
CHEMBL3287082
Type:
Small organic molecule
Emp. Form.:
C26H22Cl2N2O6S
Mol. Mass.:
561.434
SMILES:
COc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C1CC1
Structure:
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