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Target
Estradiol 17-beta-dehydrogenase 2
Ligand
BDBM50021404
Substrate
n/a
Meas. Tech.
ChEMBL_1363494 (CHEMBL3291985)
IC50
54±n/a nM
Citation
 Perspicace, E; Cozzoli, L; Gargano, EM; Hanke, N; Carotti, A; Hartmann, RW; Marchais-Oberwinkler, S Novel, potent and selective 17ß-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities. Eur J Med Chem 83:317-37 (2014) [PubMed]  Article 
Target
Name:
Estradiol 17-beta-dehydrogenase 2
Synonyms:
17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_MOUSE | Edh17b2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase
Type:
PROTEIN
Mol. Mass.:
41847.95
Organism:
Mus musculus
Description:
ChEMBL_104366
Residue:
381
Sequence:
MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH
  
Inhibitor
Name:
BDBM50021404
Synonyms:
CHEMBL3289873
Type:
Small organic molecule
Emp. Form.:
C21H20FNO3S
Mol. Mass.:
385.452
SMILES:
COc1cccc(-c2cc(C)c(s2)C(=O)N(C)Cc2cccc(O)c2)c1F
Structure:
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