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Target
1-deoxy-D-xylulose-5-phosphate synthase
Ligand
BDBM50026348
Substrate
n/a
Meas. Tech.
ChEMBL_1441266 (CHEMBL3380656)
Ki
10400±n/a nM
Citation
 Masini, T; Hirsch, AK Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents. J Med Chem 57:9740-63 (2014) [PubMed]  Article 
Target
Name:
1-deoxy-D-xylulose-5-phosphate synthase
Synonyms:
1-deoxy-D-xylulose-5-phosphate synthase | 1-deoxyxylulose-5-phosphate synthase | DXP synthase | DXPS | DXS_ECO27 | dxs
Type:
PROTEIN
Mol. Mass.:
67649.22
Organism:
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Description:
ChEMBL_109718
Residue:
620
Sequence:
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNAVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLLDFFIPQGTQEEMRAELGLDATGMEAKIKAWLA
  
Inhibitor
Name:
BDBM50026348
Synonyms:
CHEMBL3359030
Type:
Small organic molecule
Emp. Form.:
C9H11O4P
Mol. Mass.:
214.155
SMILES:
CC(=O)P(O)(=O)OCc1ccccc1
Structure:
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