Reaction Details Report a problem with these data
Target
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Ligand
BDBM50027370
Substrate
n/a
Meas. Tech.
ChEMBL_1441304 (CHEMBL3371548)
IC50
6400±n/a nM
Citation
 Swarbrick, JM; Graeff, R; Zhang, H; Thomas, MP; Hao, Q; Potter, BV Cyclic adenosine 5'-diphosphate ribose analogs without a"southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38. J Med Chem 57:8517-29 (2014) [PubMed]  Article 
Target
Name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Synonyms:
CD38 | CD38_HUMAN | Lymphocyte differentiation antigen CD38
Type:
PROTEIN
Mol. Mass.:
34333.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1509931
Residue:
300
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
  
Inhibitor
Name:
BDBM50027370
Synonyms:
CHEMBL3342440
Type:
Small organic molecule
Emp. Form.:
C14H19N7O11P2
Mol. Mass.:
523.2885
SMILES:
[H][C@]12COP(O)(=O)OP(O)(=O)OCCCCn3c(N=[N+]=[N-])nc4c3ncn(c4=O)[C@]([H])(O1)[C@H](O)[C@@H]2O |r|
Structure:
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