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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50031298
Substrate
n/a
Meas. Tech.
ChEMBL_1432525 (CHEMBL3386957)
IC50
4900±n/a nM
Citation
 Qin, YJ; Wang, PF; Makawana, JA; Wang, ZC; Wang, ZN; Yan-Gu, na; Jiang, AQ; Zhu, HL Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. Bioorg Med Chem Lett 24:5279-83 (2014) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50031298
Synonyms:
CHEMBL3352863
Type:
Small organic molecule
Emp. Form.:
C22H19BrN6O3S
Mol. Mass.:
527.394
SMILES:
Cc1ncc(n1CCOc1ccc(\C=N\Nc2nc(cs2)-c2ccccc2Br)cc1)[N+]([O-])=O
Structure:
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