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Target
Protein phosphatase 1G
Ligand
BDBM50343530
Substrate
n/a
Meas. Tech.
ChEMBL_1438616 (CHEMBL3386721)
IC50
74800±n/a nM
Citation
 Hou, X; Li, R; Li, K; Yu, X; Sun, JP; Fang, H Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening. J Med Chem 57:9309-22 (2014) [PubMed]  Article 
Target
Name:
Protein phosphatase 1G
Synonyms:
PP2C-gamma | PPM1C | PPM1G | PPM1G_HUMAN | Protein phosphatase 1C | Protein phosphatase 1G | Protein phosphatase 2C isoform gamma | Protein phosphatase magnesium-dependent 1 gamma
Type:
PROTEIN
Mol. Mass.:
59199.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109523
Residue:
546
Sequence:
MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKKKKAKRD
  
Inhibitor
Name:
BDBM50343530
Synonyms:
5,7-dichloro-4-((3-(4-methoxyphenylthio)benzyl)(methyl)amino)quinoline-2-carboxylic acid | CHEMBL1774309
Type:
Small organic molecule
Emp. Form.:
C25H20Cl2N2O3S
Mol. Mass.:
499.409
SMILES:
COc1ccc(Sc2cccc(CN(C)c3cc(nc4cc(Cl)cc(Cl)c34)C(O)=O)c2)cc1
Structure:
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