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Target
Kinesin-like protein KIFC1
Ligand
BDBM50216502
Substrate
n/a
Meas. Tech.
ChEMBL_1438848 (CHEMBL3390316)
IC50
>100000±n/a nM
Citation
 Yang, B; Lamb, ML; Zhang, T; Hennessy, EJ; Grewal, G; Sha, L; Zambrowski, M; Block, MH; Dowling, JE; Su, N; Wu, J; Deegan, T; Mikule, K; Wang, W; Kaspera, R; Chuaqui, C; Chen, H Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. J Med Chem 57:9958-70 (2014) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIFC1
Synonyms:
HSET | HSET | KIFC1 | KIFC1_HUMAN | KNSL2 | Kinesin-like protein 2 | Kinesin-like protein KIFC1 | Kinesin-related protein HSET
Type:
PROTEIN
Mol. Mass.:
73763.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109524
Residue:
673
Sequence:
MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATTKITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTSGVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKALGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEERRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRLHNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHSVFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANRK
  
Inhibitor
Name:
BDBM50216502
Synonyms:
4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester | CHEMBL236789 | monastrol | rac-monastrol
Type:
Small organic molecule
Emp. Form.:
C14H16N2O3S
Mol. Mass.:
292.353
SMILES:
CCOC(=O)C1C(NC(=S)N=C1C)c1cccc(O)c1 |w:6.13,c:10|
Structure:
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